Studies on Synthesis of 2-Keto-4-(5'-nitro-2'-furyI)-5-carbethoxy-6-methyl-1, 2, 3, 4-tetrahydropyrimidine
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چکیده
منابع مشابه
Synthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines
A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...
متن کاملSynthesis and Leishmanicidal Activity of 1-[5-(5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl]-4-benzoylepiperazines
A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...
متن کاملSynthesis and Biological activity of new 5-Methyl-3-Oxo-N2 [5’- Carbonyl-(4’-Aryl-6’methyl)-1’,2’,3’,4’–Tetrahydropyrimidine-2’- One]Pyrazolidines
INTRODUCTION In recent years, synthesis of combination towards various heterocyclic rings has been interest for the source of lead molecules possesses wide range of pharmacological activities. Most of the compounds having pyrimidine and pyrazolidinone nucleus exhibits pharmacological action. [1-3].A broad spectrum of biological activities like antiinflammatory [4], antibacterial [5], antifungal...
متن کاملsynthesis and antioxidant evaluation of 4-(furan-2-yl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate esters
biginelli-type pyrimidines contain an interesting moiety which has attracted considerable attention of medicinal chemists in the last few decades. despite the very diverse pharmacologic effects ascribed to this kind of pyrimidines, there are few reports on the antioxidant evaluation of biginelli pyrimidines. in this study synthesis of some novel biginelli-type pyrimidines is reported. the prepa...
متن کاملMethyl 2-benzyl-5-[1-(4-methoxyphenyl)-4-oxo-3-phenylazetidin-2-yl]-4-nitro-3-phenylpyrrolidine-2-carboxylate
In the title mol-ecule, C(35)H(33)N(3)O(6), the pyrrolidine ring adopts a twist conformation. The mol-ecules are paired into centrosymmetric dimers by weak inter-molecular C-H⋯O hydrogen bonds. The dimers inter-act further again via C-H⋯O hydrogen bonds and N-H⋯O intramolecular interaction also stabilize the crystal packing.
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ژورنال
عنوان ژورنال: Nippon kagaku zassi
سال: 1964
ISSN: 0369-5387,2185-0917
DOI: 10.1246/nikkashi1948.85.52